Twilio + Zendesk workflows
MESA is the fastest way to automate Twilio to Zendesk. MESA gives you complete control over which fields you send, how they're formatted, and when the sync happens, all without touching a line of code. Start with a pre-built template that matches your needs, customize it with the help of AI, or build something completely unique in under 10 minutes.
No templates yet? We'll help you build it
Our automation experts can help you create a custom Twilio to Zendesk workflow tailored to your needs.
Get hands-on support from our team to design and set up the workflow you're after—no code required.
Get help building your workflow →1,000+ merchants trust MESA to help them multiply their impact without multiplying their work.
Ready to integrate Twilio with Zendesk? Try MESA free for 7 days.
Our support team will help you set up your first workflow for free.
Build any workflow with these Twilio and Zendesk steps
Making workflows is easy. Triggers start a workflow then, actions occur when it's running. Read more Twilio docs in our knowledge base.
Why automate Twilio to Zendesk?
Twilio to Zendesk automations get more done in less time. Automate the everyday tasks holding back your potential growth.
Send SMS notifications from Shopify order and fulfillment events
When an order is placed, shipped, or delivered in Shopify, MESA triggers the right Twilio SMS with the relevant details already populated. Your customers get accurate, timely messages on the channel they actually check without anyone manually initiating them.
Alert your team via SMS when a Shopify event needs immediate attention
When a high-value order comes in, a fulfillment exception occurs, or a VIP customer shows a churn signal, MESA sends a Twilio SMS to the right person on your team. Critical events reach the right person instantly without relying on someone checking email or Slack.
Trigger Shopify workflows from inbound Twilio SMS responses
When a customer replies to a Twilio message — confirming an order, requesting a change, responding to a survey — MESA reads the response and kicks off the corresponding action in Shopify. Your SMS channel becomes a two-way workflow trigger, not just an outbound notification pipe.
Create Zendesk tickets from Shopify order events automatically
When an order is flagged — a failed fulfillment, a return request, a delayed shipment — MESA opens a ticket in Zendesk with the order details already attached. Your support team works the issue without hunting for context.
Keep Shopify customer data current when tickets are resolved
When a Zendesk ticket is closed or a resolution is logged, MESA updates the customer's record in Shopify — tags, notes, fields. Your store reflects what your support team learned without anyone syncing it manually.
Route support tickets based on order and customer details
When a ticket arrives in Zendesk, MESA reads the associated Shopify data — order value, customer tier, product type — and applies the right tags, priority, or assignee. Every ticket lands with the right team from the start.
Automate your work in less clicks
MESA makes automation achievable so you can multiply your impact without multiplying the work.
Try MESA for free 7-day trial included. Cancel anytime.Expert support included
MESA includes hands-on support from automation experts who know how to get things done.
Free workflow setup
Book a session and we'll build your first workflow with you—live. Most merchants walk away with automation saving 5+ hours/week.
Fast response times
Average first response: Same day, Critical issues: Immediate escalation
Complex builds: 24-48 hours
Managed services available
Personalized workflow reviews, and quarterly check-ins to identify new automation opportunities as your business grows.
Real humans, always
Live chat with real automation experts (not bots). Email support monitored 9am-5pm PST. Google Meet sessions for complex workflows.






